Blog about viagra

This is a very serious issue and hence there are different claims from both sides; who say that Viagra does causes infertility and even those people are also not hard find that are authentic, qualified and apprehensive, who say that Viagra is absolutely safe and has nothing to do with infertility that comes with proof too which also is a matter of huge concern because this adds more to the confusion.
A research was carried out that showed that Viagra makes the sperm very active but it causes a very adverse effect as the sperm release digestive enzymes which pierce the egg wall to fertilize it before it has reached the egg. When it does reach the egg it cannot pierce the wall, as due to the over excitement in the sperm due to the intake of Viagra this research was not taken that seriously on the basis of this argument by Pfizer that it was not carried on humans and it sounds very convincing too But that persuasion didn’t last long as recently there was another research carried out that showed its adverse effects on male fertility and caused the same effect as that did on the rats that were previously tested.
This research was also very effectively refuted and a befitting reply was made in reaction to this research as this could prove to be a major set back; as those aspiring men who were planning for conceiving a child would quit that without a second thought. It was said that the internal functioning of sperm is different to the environment under which they carried the researches and contrary to what they pictured Sildenafil can act as a fertility booster as it causes a neural stimulation that releases three times the Oxytocin; where Oxytocin is a hormone that plays an important role in sexual arousal, social interactions, and reproduction. Some specific functions of Oxytocin include initiating uterine contraction during labor and triggering lactation. Another study has also linked Oxytocin to the formation of strong social bonds.

As they say nothing in this world is perfect and that is in both contexts; positive and negative. As every thing that is developed, discovered or natural it goes through a process of evolution and if anything that is good can not always remain good and what is bad does not means that it always has to remain bad. Viagra too has the similar story; as researches have been constantly carried out to improve the performance of the drug and minimize the impact of the side effects caused by Viagra. They also carry out studies on whether Viagra can be useful in treating other diseases or not.

Viagra has been recently reported to help in treating breast cancer, leukemia and sarcomas. As Viagra stabilizes the mitochondria and protects against free-radical damage of the mitochondria, which could other wise result in some serious situation. It has been also reported that it can be handy in removing clots; as Stents, which are installed in the arteries to maintain blood flow through them, the foreign materials of the devices, are recognized by the body and platelets often clot to them. If too many clot, this can block blood flow, potentially inducing a stroke or heart attack.

A lot of research has been done specially in the initial days of Viagra’s advent as it caused a stir throughout America and many said that it has completed changed the sex life of America but there were people who had also complaints and large contingent were that of women. Where they said that it takes two to tango and all the focus is on male sex drive and talk about their Sexual or Erectile Dysfunction but there is no mentioning of the problems women were facing and now Viagra had added more to the confusion as the male partner wants it badly but women are hardly interested in sex due to their Female Sexual Dysfunction which has many reasons to blame for. Eventually which turn the bed into a battle field.
Though there have been cases where Viagra is tested over females but the results didn’t had any major breakthrough. Some doctors do prescribed it but the results were not as wondrous as they are with male. As the mechanism of the working of the Viagra would all do in women is to fill their genitals with blood and that’s it; along with the usual side effects that occur with the usage of Viagra. Upon the reported sexual stimulation of some patients; when asked experts they said it’s purely due to psychological reasons and had nothing to do with Viagra.
Where Pfizer have categorically said that Viagra is only for patients with erectile dysfunction and Viagra is not for newborns, children, or women.

The primary use though of Viagra is for erectile dysfunction and the inhibition of cGMP specific phosphodiesterase type 5 enzyme. But it has been observed that it is useful in treatment of some other diseases as well. Those are listed below

Pulmonary Arterial Hypertension:
Sildenafil Citrate is also useful for the treatment of Pulmonary Arterial Hypertension (PAH). The solution is named Revatio, to avoid confusion with Viagra, and they are white and round. Pfizer in 1995 submitted an additional registration for Sildenafil to the Food and Drug Association (FDA). It relaxes the arterial wall, leading to decreased pulmonary arterial resistance and pressure. This in turn reduces the workload of the right ventricle of the heart and improves symptoms of right-sided heart failure. Because PDE-5 is primarily distributed within the arterial wall smooth muscle of the lungs and penis, Sildenafil acts selectively in both these areas without inducing vasodilatation in other areas of the body.

Altitude Sickness:
Altitude sickness is a state which mountain climbers most complain about and recently It has been discovered that Sildenafil has been useful for the prevention and treatment of altitude sickness. Sildenafil is now already becoming an accepted treatment for this condition.
Performance Enhancers:
Professional sports players have been using drugs such as Viagra thinking that the opening of their blood vessels will enrich their muscles, therefore enhancing their performance. Soccer star Pele´ has been openly endorsing it.

Following is the list of those people who are prone to some serious side effects and are categorically advised not to take Viagra as it can cause serious repercussion for them. If they have a medical history related to heart diseases, stroke or taking any medication that can not go well with Viagra they are strictly prohibited from the use of Viagra.

You are not supposed to take Viagra if you are using drugs for Chest Pain or heart problem. This includes nitroglycerin (Nitrostat, Nitrolingual, Nitro-Dur, Nitro-Bid, and others), isosorbide dinitrate (Dilatrate-SR, Isordil, Sorbitrate), and isosorbide mononitrate (Imdur, ISMO, Monoket). Nitrates are also found in some recreational drugs such as amyl nitrate or nitrite (”poppers”). As Taking Sildenafil with a nitrate medicine can cause a serious decrease in blood pressure, leading to fainting, stroke or heart attack; as Sildenafil core function is to meddle with how the heart functions; therefore Viagra combine with the effects of these drugs, is the perfect recipe for disaster.

A number of people have been reported a sudden loss of vision after the intake Sildenafil. This type of vision loss is caused by decreased blood flow to the optic nerve of the eye. This sudden loss of vision has been widely reported in patient having history of heart disease, diabetes, high blood pressure, high cholesterol, or certain pre-existing eye problems, and in those who smoke or are over 50 years old.

Before taking Sildenafil, tell your doctor if you have:

Heart disease or heart rhythm problems
A recent history (in the past 6 months) of a heart attack, stroke, or heart rhythm disorder
Congestive heart failure
High or low blood pressure
Coronary artery disease
Liver disease
Kidney disease
A blood cell disorder such as sickle cell anemia, multiple myeloma, or leukemia
A bleeding disorder such as hemophilia
A stomach ulcer
Retinitis pigmentosa (an inherited condition of the eye)
A physical deformity of the penis (such as peyronie’s disease)
If you have been told you should not have sexual intercourse for health reasons

Here are some side effects that may occurs provided some of the enabling factors that are there and at the emergence of such situations immediately call a doctor

If dizziness, nausea or pain, numbness or tingling in the chest, arms, neck or jaw during sexual activity are experienced; Immediately seek the help of the doctor

At the time of sudden loss of vision after the intake of Sildenafil, without any delay see a doctor.

After the intake Sildenafil if you experience the following allergies that are hives, difficulty breathing, swelling of face, lips, tongue, or throat immediately seek the help of a doctor.

At the emergence of the following complaint prior to the use of Sildenafil that are chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling. Quickly see a doctor.

Following are the side effects that are mostly reported and if these occur you are advised to immediately seek the help of the nearest doctor:

Irregular heartbeat.
Swelling in hands, ankles, or feet.
Shortness of breath.
Vision changes.
Feeling light-headed, fainting.
Penis erection that is painful or lasts 4 hours or longer.

Continue taking Sildenafil and talk with your doctor if you have any of these less serious side effects:

Warmth or redness in your face, neck, or chest.
Stuffy nose.
Headache.
Upset stomach.
Back pain.

The main ingredient of Viagra is Sildenafil Nitrate; it acts by slowing down cGMP specific phosphodiesterase type 5 which is an enzyme that is responsible for the chemical reaction to occur which determines when to relax the corpora cavernosa muscle for regulating the blood flow. Now what Sildenafil does is that it hold back this enzyme responsible for regulating the blood flow; therefore when the blood accumulates inside the penis the chemical reaction responsible to cause this enzyme cGMP specific phosphodiesterase type 5 to contract the muscle and stop the inflow which eventually leads to the outflow of blood from the penis and thus the erection is lost, it is not allowed to occur and thus the erection is sustained but at the cost of holding back the blood necessary for the other human organs to function.

Robert F. Furchgott won the Nobel Prize in Physiology or Medicine in 1998 for his discovery and analysis of endothelium-derived relaxing factor (the inhibition of cGMP specific phosphodiesterase type 5 enzyme), a key part of the Sildenafil Nitrate mechanism of action.

Though some very technical jargons, processes and formulae are involved to explain the detailed process for the working pattern of Viagra which most of the people may not be able to understand therefore explaining that would be a waste of time but we do have to discuss it; as this is something that is going to travel to your stomach, so naturally after hearing so much about this medicine one gets curious to figure out how does it function and what it is made of? So in an abstract manner but comprehensively we shall discuss its main ingredients and how it fixes the whole process.

For all the processes or functions to take place internally in the human body chemical reaction happens and for those chemical reactions to transpire; enzyme are require to occur at significant rates; where as enzymes are bi-molecules that catalyze chemical reactions.

In usual circumstances upon mental and sensory stimulation a penis transforms into an erected form and gets hard, as the blood starts to accumulate inside the penis through the chambers (one is for inflow of blood and one for outflow) called corpora cavernosa and spreads through out the penis via veins and arteries. The chambers open because the brain and local nerves causes the muscle of corpora cavernosa to relax and allow the blood to flow in but when the muscle contract it stops the inflow and thus the outflow process starts and thus the erection is lost.

To advocate the success of Viagra only the figures that shows it sales in the initial days of its launch; with sales exceeding $1 billion and till quite some time it remained the major market share holder globally, are enough to convince anyone that how effective it is.

But taking a look at the success ratio would further strengthen the belief on this medication which some has termed as Wonder Drug. Though in the later years of its use some side effects were reported; some of very serious nature but compared to the success ratio one can hardly hold back for giving it a try.

It was the first oral medication for erectile dysfunction and quite easier to acquire; its utility to be used 30-90 minuets before sexual intercourse was a very motivating factor for the user to convince for the use of this medication. As erectile dysfunction can be really embarrassing and lead to many serious repercussions. As compared to going underway expensive surgeries; using electronic gadgets and means for the treatment of erectile dysfunction in itself is a cause of mortification, rather it provide a mean for the occurrence of multiple complexes to undergo such a detailed process; taking a pill with a glass of water doesn’t seems to be much of task.

Though some of the counterfeit and clones badly tarnished the brand and its image but still It was not able to wean away much of its market share.

Alongside countless other diseases mankind faces; there is one that not only has physical stigma to it but is the source of many physiological complexes causing constant depression and embarrassment.

It is the inability to perform satisfactory sexual performance and what more alarming is that it accounts to be the major worldwide health care problem; Erectile Dysfunction, It is the inability to maintain an erection for sexual intercourse.

Sildenafil nitrate is a compound on which a group of pharmaceutical chemists working at Pfizer in a research facility in England back in 1994; studied it for use in hypertension and angina pectoris (reduced blood supply to heart muscle), later in the clinical trial it was observed that it had very little effect on angina but it could induce marked penile erections. Sensing an opportunity Pfizer therefore decided to market it as a remedy for erectile dysfunction and patented it in 1996. Later it was approved for use by United States food and Drug Administration in 1998 becoming the first oral treatment for erectile dysfunction and it soon became a huge success; where it sales between 1999-2001 exceeded $1 billion. Though in 2000 its global market share in prescribed erectile dysfunction pills was 92 percent but later with the emergence of other brands and some other factors it fell to 52 percent in 2007. The Pfizer’s patent on Sildenafil nitrate will expire in 2011-13.